Proving Continuity of Coinductive Global Bisimulation Distances: A Never Ending Story

We have developed a notion of global bisimulation distance between processes which goes somehow beyond the notions of bisimulation distance already existing in the literature, mainly based on bisimulation games. Our proposal is based on the cost of transformations: how much we need to modify one of the compared processes to obtain the other. Our original definition only covered finite processes, but a coinductive approach allows us to extend it to cover infinite but finitary trees. After having shown many interesting properties of our distance, it was our intention to prove continuity with respect to projections, but unfortunately the issue remains open. Nonetheless, we have obtained several partial results that are presented in this paper.Comment: In Proceedings PROLE 2015, arXiv:1512.0617

Revisiting logical semantics for processes and their distances

Tesis inédita de la Universidad Complutense de Madrid, Facultad de Informática, Departamento de Sistemas Informáticos y Computación, leída el 2-02-2016Esta tesis se enmarca en el amplio campo de la teoría de la concurrencia. Más específicamente, nos centramos en el estudio de las relaciones de similitud entre procesos concurrentes. Comenzamos estudiando la bisimulación, considerada la más importante de estas relaciones, y vemos después cómo podemos extender nuestros resultados al resto de las semánticas de procesos estudiadas durante las últimas décadas. En particular, nuestra contribución a la comunidad científica, se centra en dos puntos principales: – El desarrollo de una caracterización lógica uniforme de las semánticas de procesos: proponemos un esquema lógico común (enmarcado en la conocida lógica modal de Hennessy-Milner) e incluimos las diferentes semánticas en este esquema, enfatizando las diferencias y similitudes entre ellas, que se presentan del modo más claro posible. – La presentación de una nueva noción de distancia, tanto entre procesos finitos como infinitos: la misma se diferencia de las anteriormente propuestas en su carácter global, que acumula las diferencias que aportan los distintos cómputos, en lugar de quedarnos con la máxima de ellas...This thesis can be included in the broad field of concurrency theory. More specifically, we focus on the study of the similarities between concurrent processes. We start from bisimulation, the main of these relations, and then we see how we can extend the obtained results to the rest of the semantics developed along the last years. In particular, our main contributions can be roughly described by the following two items: – The development of a unified logical characterization of process semantics: we propose a common logical scheme (within the framework of the well known Hennessy-Milner Logic) and we set the different semantics in this scheme by emphasizing, in the clearest possible way, the (dis)similarities between them. – We present a new notion of distance for both finite and infinite processes. This novel notion differs from the previously available ones in its global character: instead of taking the maximum disagreement between the two compared processes, it adds all the differences provided by their whole sets of computations...Depto. de Sistemas Informáticos y ComputaciónFac. de InformáticaTRUEunpu

Site-specific bacterial chromosome engineering mediated by IntA integrase from Rhizobium etli

Background: The bacterial chromosome may be used to stably maintain foreign DNA in the mega-base range. Integration into the chromosome circumvents issues such as plasmid replication, stability, incompatibility, and copy number variance. The site-specific integrase IntA from Rhizobium etli CFN42 catalyzes a direct recombination between two specific DNA sites: attA and attD (23 bp). This recombination is stable. The aim of this work was to develop a R. etli derivative that may be used as recipient for the integration of foreign DNA in the chromosome, adapting the IntA catalyzed site-specific recombination system. Results: To fulfill our aim, we designed a Rhizobium etli CFN42 derivative, containing a “landing pad” (LP) integrated into the chromosome. The LP sector consists of a green fluorescent protein gene under the control of the lacZ promoter and a spectinomycin resistance gene. Between the lacZ promoter and the GFP gene we inserted an IntA attachment site, which does not affect transcription from the lac promoter. Also, a mobilizable donor vector was generated, containing an attA site and a kanamycin resistance gene; to facilitate insertion of foreign DNA, this vector also contains a multicloning site. There are no promoters flanking the multicloning site. A biparental mating protocol was used to transfer the donor vector into the landing pad strain; insertion of the donor vector into the landing pad sector via IntA-mediated attA X attA recombination thereby interrupted the expression of the green fluorescent protein, generating site-specific cointegrants. Cointegrants were easily recognized by screening for antibiotic sensitivity and lack of GFP expression, and were obtained with an efficiency of 6.18 %. Conclusions: Integration of foreign DNA in Rhizobium, lacking any similarity with the genome, can be easily achieved by IntA-mediated recombination. This protocol contains the mating and selection procedures for creating and isolating integrants.Fil: Hernández Tamayo, Rogelio. Universidad Nacional Autónoma de México; MéxicoFil: Torres Tejerizo, Gonzalo Arturo. Universidad Nacional Autónoma de México; México. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Brom, Susana. Universidad Nacional Autónoma de México; MéxicoFil: Romero, David. Universidad Nacional Autónoma de México; Méxic

Diseño Y Validación De Un Modelo Antropométrico Para Evaluar La Masa Grasa Corporal En Mujeres Mexicanas

Objective: Develop a multiple linear model, using the least squares method to correlate fat mass (kg), using anthropometric variables obtained from a sample of women from northwest Mexico. Materials: ISAK standardization was used in this study to collect measurements. The statistical criteria R², EER, VIF, Cp, and RMSE were used to evaluate the performance of the model. Method: Descriptive observational cross-sectional study to determine the fat mass of a sample of 95 women from the northwest of Mexico with normal weight and overweight. Results: The adjusted model (M8p) is made up of eight predictors that are statistically most representative in this study: weight, 6 skinfolds, and biliocrestal diameter. The fat mass of the sample was determined using air displacement plethysmography (reference), the mean obtained for the fat mass was 21.3 kg with a standard deviation of ±9.3, the M8p model predicts 20.9±9.9 kg which is 2% below the reference method used. The statistical criteria of the adjusted model are, R²Adj=0.92, SER= 2.9 kg, VIF 4.8, Cp= 7.8, and RMSE= 3.08 obtained with the adjustment sample (70 women), the validation sample (25 women) obtained a value RMSE of 3.15, so the model has predictive capacity. Conclusions: The developed model adequately predicts the fat mass of women with and without excess body fat mass, which makes it valid for use in similar samples, giving the health professional one more option to adequately evaluate this tissue, which will allow giving a optimal treatment on an individualized basis.Objetivo: Desarrollar un modelo lineal múltiple, usando el método de mínimos cuadrados para correlacionar la masa grasa (kg), utilizando variables antropométricas obtenidas de una muestra de mujeres del noroeste de México. Materiales. La estandarización ISAK fue utilizada en este estudio para el levantamiento de las mediciones. Los criterios estadísticos R², EER, VIF, Cp, y RMSE se utilizaron para evaluar el desempeño del modelo. Método. Estudio transversal observacional descriptivo, para determinar la masa grasa de una muestra de 95 mujeres del noroeste de México con normopeso y sobrepeso. Resultados. El modelo ajustado (M8p) se conforma por ocho predictores estadísticamente más representativos en este estudio: peso, 6 pliegues cutáneos y el diámetro biliocrestal. La masa grasa de la muestra se determinó usando pletismografía por desplazamiento de aire (referencia), la media obtenida para la masa grasa fue de 21.3 kg con una desviación estandar de ±9.3, el modelo M8p predice 20.9±9.9 kg lo cual está 2% debajo del método de referencia utilizado. Los criterios estadísticos del modelo ajustado son, R²Adj=0.92, EER= 2.9 kg, VIF 4.8, Cp= 7.8, y RMSE= 3.08 obtenidos con la muestra de ajuste (70 mujeres), la muestra de validación (25 mujeres) obtuvo un valor RMSE de 3.15, por lo que el modelo presenta capacidad predictiva. Conclusiones. El modelo desarrollado predice adecuadamente la masa grasa de mujeres con y sin exceso de masa grasa corporal, lo cual lo hace valido para su uso en muestras similares, dando al profesional de salud una opción más de evaluar adecuadamente este tejido, lo que permitirá dar un tratamiento óptimo de forma individualizada

Smart Device for the Determination of Heart Rate Variability in Real Time

This work presents a first approach to the design, development, and implementation of a smart device for the real-time measurement and detection of alterations in heart rate variability (HRV). The smart device follows a modular design scheme, which consists of an electrocardiogram (ECG) signal acquisition module, a processing module and a wireless communications module. From five-minute ECG signals, the processing module algorithms perform a spectral estimation of the HRV. The experimental results demonstrate the viability of the smart device and the proposed processing algorithms.Fundación Pública Andaluza Progreso y Salud. Gobierno de Andalucía PI-0010-2013 y PI-0041-2014Ministerio de Economía y Competitividad (Instituto de Salud Carlos III) PI15 / 00306 y DTS15 / 00195CIBER-BBN INT-2-CAR

Sensor Technologies to Manage the Physiological Traits of Chronic Pain: A Review

Non-oncologic chronic pain is a common high-morbidity impairment worldwide and acknowledged as a condition with significant incidence on quality of life. Pain intensity is largely perceived as a subjective experience, what makes challenging its objective measurement. However, the physiological traces of pain make possible its correlation with vital signs, such as heart rate variability, skin conductance, electromyogram, etc., or health performance metrics derived from daily activity monitoring or facial expressions, which can be acquired with diverse sensor technologies and multisensory approaches. As the assessment and management of pain are essential issues for a wide range of clinical disorders and treatments, this paper reviews different sensor-based approaches applied to the objective evaluation of non-oncological chronic pain. The space of available technologies and resources aimed at pain assessment represent a diversified set of alternatives that can be exploited to address the multidimensional nature of pain.Ministerio de Economía y Competitividad (Instituto de Salud Carlos III) PI15/00306Junta de Andalucía PIN-0394-2017Unión Europea "FRAIL

Special Issue “Body Sensors Networks for E-Health Applications”

Body Sensor Networks (BSN) have emerged as a particularization of Wireless Sensor Networks (WSN) in the context of body monitoring environments, closely linked to healthcare applications. These networks are made up of smart biomedical sensors that allow the monitoring of physiological parameters and serve as the basis for e-Health applications. This Special Issue collects some of the latest developments in the field of BSN related to new developments in biomedical sensor technologies, the design and experimental characterization of on-body/in-body antennas and new communication protocols for BSN, including some review studies

Lessons Learned about the Design and Active Characterization of On-Body Antennas in the 2.4 GHz Frequency Band

This work addresses the design and experimental characterization of on-body antennas, which play an essential role within Body Sensor Networks. Four antenna designs were selected from a set of eighteen antenna choices and finally implemented for both passive and active measurements. The issues raised during the process of this work (requirements study, technology selection, development and optimization of antennas, impedance matching, unbalanced to balanced transformation, passive and active characterization, off-body and on-body configurations, etc.) were studied and solved, driving a methodology for the characterization of on-body antennas, including transceiver effects. Despite the influence of the body, the antennas showed appropriate results for an in-door environment. Another novelty is the proposal and validation of a phantom to emulate human experimentation. The differences between experimental and simulated results highlight a set of circumstances to be taken into account during the design process of an on-body antenna: more comprehensive simulation schemes to take into account the hardware effects and a custom design process that considers the application for which the device will be used, as well as the effects that can be caused by the human body.Ministerio de Economía y Competitividad (Instituto de Salud Carlos III) PI15/00306Junta de Andalucía PIN-0394-2017Unión Europea "FRAIL

Las estrategias de búsqueda visual de juegadores expertos de tenis en silla de ruedas

El presente trabajo aborda el estudio de las estrategias de búsqueda visual de jugadores expertos de tenis en silla de ruedas. Pretende contrastar la existencia o no de un patrón visual para la obtención de información del entorno y las posibles similitudes en el mismo intra sujetos, así como las diferencias en las estrategias empleadas cuando se visualiza a un oponente al servicio. Para ello se studiaron a 6 tenistas correspondientes a los 10 primeros del ranking espanol. El registro se llevó a cabo mediante el sistema de seguimiento de la mirada ASL SE5000 en situación de laboratorio (2D) de dos secuencias de saques de un mismo modelo en silla de ruedas y en posición bípeda. Los resultados btenidos revelan que no hay diferencias entre los procesos seguidos en las visualizaciones de los saques en silla y de pie, así como la no correspondencia entre los datos registrados y la información verbal obtenida acerca de los procesos perceptivos seguidos mediante el empleo de un cuestionario.The visual search strategies employed by expert wheelchair tennis players were investigated. We explored the existence of an expert pattern to obtain visual information from the environment. Moreover, differences and similarities within subjects will be studied. The visual behaviors of six players (they are in the top-ten Spanish ranking) were recorded by eye tracking system ASL SE5000. The subjects watched two series of video projections of wheelchair-tennis serves and regular tennis serves. Results show no differences in visual strategies when subjects watched wheelchair and non-wheelchair trials. Results also show no relation between visual strategies and verbal reports

Properties of the (n, m)−fold hyperspace suspension of continua

Let n, m ∈ N with m ≤ n and X be a metric continuum. We consider the hyperspaces Cn(X) (respectively, Fn(X)) of all nonempty closed subsets of X with at most n components (respectively, n points). The (n, m)−fold hyperspace suspension on X was introduced in 2018 by Anaya, Maya, and Vázquez-Juárez, to be the quotient space Cn(X)/Fm(X) which is obtained from Cn(X) by identifying Fm(X) into a one-point set. In this paper we prove that Cn(X)/Fm(X) contains an n−cell; Cn(X)/Fm(X) has property (b); Cn(X)/Fm(X) is unicoherent; Cn(X)/Fm(X) is colocally connected; Cn(X)/Fm(X) is aposyndetic; and Cn(X)/Fm(X) is finitely aposyndeticSean n, m ∈ N con m ≤ n y X es un continuo métrico. Consideramos el hiperespacio de todos los subconjuntos cerrados, no vacíos de X con a lo más n componentes (respectivamente, n puntos) Cn(X) (respectivamente, Fn(X)). El (n, m)−ésimo hiperespacio suspensión de X lo introdujeron, en 2018, Anaya, Maya y Vázquez-Juárez, como el espacio cociente Cn(X)/Fm(X) que se obtiene de Cn(X) al identificar Fm(X) a un conjunto de un punto. En este artículo demostramos que Cn(X)/Fm(X) contiene una n−celda; Cn(X)/Fm(X) tiene la propiedad (b); Cn(X)/Fm(X) is unicoherente; Cn(X)/Fm(X) es colocalmente conexo; Cn(X)/Fm(X) es aposindético y Cn(X)/Fm(X) es finitamente aposindético